The purpose is to present commissioning data for the MOBETRON electron radiation therapy system (IntraOp) at ultra-high dose rate using the HYPERSCINT plastic scintillation detector. The suitability of using a plastic scintillator as an active dosimeter for commissioning measurements of an ultra-high dose rate electron beam has been demonstrated (reference dosimetry, DPP, beam penetration, linearity with number of pulses, linearity with PW and short-term output stability).
The objective is to investigate a plasmid DNA nicking assay approach for isolating and quantifying the DNA-damaging effects of ultrahigh-dose-rate (ie FLASH) irradiation relative to conventional dose-rate irradiation. The doses and dose rates were verified independently using EBT-XD Gafchromic film placed directly above the DNA-based phantom and HYPERSCINT high temporal resolution plastic scintillator placed immediately beside the DNA phantoms (both phantoms had been previously calibrated at conventional dose rates and validated at FLASH-RT dose rates).
To present an x-ray tube system capable of in vitro ultrahigh dose-rate (UHDR) irradiation of small < 0.3 mm samples and to characterize it by means of a plastic scintillation detector (PSD).
To examine the capabilities of plastic scintillator dosimeters (PSDs) to accurately measure FLASH radiotherapy dose rates delivered with an x-ray tube.
To examine the capabilities of plastic scintillators of different compositions to accurately measure dose in high dose-rate dose irradiations delivered with an x-ray tube.
FLASH-Radiotherapy is an emerging ultrahigh dose rates radiotherapy technique, and animal studies have demonstrated the safety and efficacy of the technique in cancer treatment. A reliable real-time dosimeter system is crucial for the characterization of the so-called ‘FLASH-effect’, and an accurate beam delivery. This study aims to benchmark the performance of optical fiber inorganic scintillating detectors (ISDs) with plastic scintillating detectors (PSDs) for an ultrahigh dose-rate x-ray beam irradiation. Measurements includes : relative scintillator output, signal linearity with dose and dose rate, signal-to-noise ratio (SNR), signal stability and reliability.
The PSDs resulted in the highest reliability for a UHDR beam measurement with a CV of <0.1% while the Gd2O2S:Tb showed excellent repeatability (coefficient of variation (CV) <0.1%) compared to other detectors. All detectors showed good linearity with tube current (R2 < 0.975) and shutter exposure (R2 >0.999).
FLASH radiation therapy using an ultrahigh dose-rate beam is found to eradicate tumours whilst significantly reducing radiation-induced tissue toxicity. A real-time dosimetry system is required for the technique to be implemented clinically and for further preclinical studies. This study aimed to optimize the design of scintillating detectors using inorganic materials for real-time dosimetry in ultrahigh dose-rate radiation applications. Inorganic scintillator detectors were fabricated using phosphor-based scintillating materials (Gd2O2S:Tb, La2O2S:Tb, and La2O2S:Eu) coupled with optical fibers. The initial results in ultrahigh dose-rate x-ray irradiation showed excellent linearity with signal independent of the dose rate and dose delivered. A hyperspectral approach is adopted in this study to account for the stem effect that occurs within the high energy typically used in radiotherapy.