Technical note: Characterization and practical applications of a novel plastic scintillator for online dosimetry for an ultrahigh dose rate (FLASH)

Although flash radiation therapy (FLASH-RT) is a promising novel technique that has the potential to achieve a better therapeutic ratio between tumor control and normal tissue complications, the ultrahigh pulsed dose rates (UHPDR) mean that experimental dosimetry is very challenging.

Med Phys. 2022
Y.Poirier (1,2), J.Xu (1), S.Mossahebi (1), F.Therriault-Proulx (3), A.Sawant (1) | Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, USA, Department of Medical Physics, McGill University, Montreal, Quebec, Canada, MedScint, QC, CA

FLASH Irradiation of Drosophila Melanogaster Using Low Energy X-Rays

To investigate the capability of low energy x-rays to elicit the FLASH effect, Drosophila melanogaster larvae were irradiated with ultrahigh dose-rate (UHDR) and conventional radiotherapy (CONV-RT) dose rates using an inexpensive x-ray tube system.

2022 AAPM AM
A.Hart, J.Dudzic, J.Eby, S.Perlman, M.Bazalova-Carter | University of Victoria, Victoria, BC ,CA

Quantifying the DNA-damaging Effects of FLASH Irradiation With Plasmid DNA

To investigate a plasmid DNA nicking assay approach for isolating and quantifying the DNA-damaging effects of ultrahigh-dose-rate (ie, FLASH) irradiation relative to conventional dose-rate irradiation.

Int J Radiat Oncol Biol Phys. 2022
A.Perstin (1), Y.Poirier (2), A.Sawant (2), M.Tambasco (3) | Department of Physics, San Diego State University, San Diego, California (1), Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, USA (2), Department of Physics, San Diego State University, San Diego, California, USA (3)

Characterization of an x‐ray tube‐based ultrahigh dose‐rate system for in vitro irradiations.

To present an x-ray tube system capable of in vitro ultrahigh dose-rate (UHDR) irradiation of small < 0.3 mm samples and to characterize it by means of a plastic scintillation detector (PSD).

Med Phys. 2021
D.Cecchi (1), F.Therriault-Proulx (2), S.Lambert-girard (2), A.Hart (1), A.Macdonald (1), M.Pfleger (1), M.Lenckowski (1), M.Bazalova-Carter (1) | Department of Physics and Astronomy, University of Victoria, Victoria, British Columbia, Canada, MedScint, QC, CA