Development of End-to-End Preclinical Treatment Verification Procedures, Traceable to NPL Air Kerma Primary Standard

Dosimetry audits are an important tool to improve quality of reported results and to support standardization of preclinical radiation research. This work presents how the combination of passive and active detectors, such as the real-time HYPERSCINT scintillation dosimetry solution, with anatomically correct mouse phantoms are adequate for the development of End-to-End dosimetry audits for the independent verification of preclinical radiation treatments.

The traceability of the detectors’ calibration to primary standards strengthens the dosimetry chain in the validation of preclinical plans, and it is consistent with the current practice for dose traceability of clinical radiotherapy treatments. Their implementation at national and regional levels could lead to databases of anonymised records, which will positively impact the dissemination of best practices and sharing of validated results.

6th Conference on small animal precision image-guided radiotherapy
Ileana Silvestre Patallo (1), Rebecca Carter (2)(3), Andrew Nisbet (2), Anna Subiel (1), Giuseppe Schettino (1) | 1. National Physical Laboratory, UK, 2. University College London, UK, 3. Cancer Institut, UK

Performance characterization of a novel hybrid dosimetry insert for simultaneous spatial, temporal, and motion-included dosimetry for MR-linac

The increased treatment complexity and the motion-delivery interplay during stereotactic body radiotherapy (SBRT) on an MR-linac treatments require MR-compatible motion phantoms with time-resolved dosimeters to validate end-to-end workflows. This study demonstrates the excellent suitability of a the Medscint novel hybrid film-scintillators cassette for simultaneous multi-spatial, temporal, and motion-included dosimetry.

MEDICAL PHYSICS
Prescilla Uijtewaal (1), Pim Borman (1), Benjamin Côté (2), Yoan LeChasseur (2), François Therriault-Proulx (2), Rocco Flores (3), Stephanie Smith (3), Grant Koenig (3), Bas Raaymakers (1), Martin Fast (1) | 1. Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands, 2. Medscint, Québec, Quebec, Canada, 3. Modus QA, London, Ontario, Canada

Performance of the HYPERSCINT scintillation dosimetry research platform for the 1.5 T MR-linac

This study demonstrates the suitability of the HYPERSCINT PSD for accurate time- resolved dosimetry measurements in the 1.5 T MR-linac. The excellent performance during continuous MR scanning and during dynamic movement indicates the great potential of the detector to validate end-to-end workflows of online adaptive radiotherapy

PHYSICS IN MEDICINE & BIOLOGY
Prescilla Uijtewaal (1), Benjamin Côté (2), Thomas Foppen (1), J H Wilfred de Vries (1), Simon J Woodings (1), Pim T S Borman (1), Simon Lambert-Girard (2), François Therriault-Proulx (2), Bas W Raaymakers (1), Martin F Fast (1) | 1 – UMC Utrecht, Netherland, 2 – Medscint, Canada

Plastic scintillation detectors: real-time dosimetry in the MR-Linac environment.

Optical innovation meets clinical translation : in the vanguard of adaptive MR/RT research effort, the UMC Utrecht research team works with plastic scintillation detectors to bring MR-Linac treatment to the next level.

PHYSICS WORLD
| UMC Utrecht, Medscint

First Experimental Demonstration of Time-Resolved Plastic Scintillation Dosimetry On An MR-Linac

In this study, UMC Utrecht research team demonstrates the feasibility of a hybrid experimental setup combining an innovative multipoint scintillator detector with film in a moving phantom quantifying MLC tracking for lung SBRT. The prototype cassette is capable of measuring dose (with film and 4 points scintillators simultaneously) during motion experiments, combining film dosimetry with time-resolved and absolute dosimetry.

2022 AAPM ANNUAL MEETING
P.Uijtewaal (1), P.Borman (1), B.Côté (2), Y.Lechasseur (2), J.Turcotte (2), S.Lambert-girard (2), P.Woodhead (1), S.Woodings (1), W.de Vries (1), R.Flores (3), S.Smith (3), B.Raaymakers (1), M.Fast (1) | 1 – UMC Utrecht, Netherland, 2 – Medscint, Canada, 3 – Modus Medical Devices, Canada

On the orientation independence of the HYPERSCINT scintillation dosimetry research platform in a MR-linac environment.

The purpose of this work was to characterize the HYPERSCINT scintillation dosimetry research platform in a MR-linac environment, particularly with respect to its orientation. This study shows that the HYPERSCINT scintillation dosimetry platform can be used regardless of its orientation in a magnetic field environment. Together with its linearity to dose and dose-rate, the detector shows great promises for development of dosimetry solutions dedicated to the MR-Linac environment.

2022 COMP ANNUAL SCIENTIFIC MEETING
B.Côté (1), B.Raaymakers (2), S.Woodings (2), P.Uijtewaal (2), W.de Vries (2), S.Lambert-girard (1), F.Therriault-Proulx (1), M.Fast (2) | Medscint, Canada (1), UMC Utrecht, Netherland (2)

Characterization of the HYPERSCINT Dosimetry System for Real-Time Dosimetry Measurements with the Varian TrueBeamLinac

Plastic scintillator/optical fibre dosimetry systems are advantageous due to their near water equivalence, waterproof construction, linear dose response, and good spatial resolution due to their small size. The nanosecond decay times of plastic scintillators enable the possibility of real-time dosimetry. We tested the new HYPERSCINT fibre detector system to determine if, in addition to the expected dose and field size responses, this system can provide real-time dose information. The HYPERSCINT system is suitable after appropriate calibration to be used to measure relative dose delivered in cGy as well as indicate changing dose conditions within 0.3 seconds.

2020 AAPM AM
C.Penner (1,2), C.Hoehr (2), C.Mendez (1), C.Duzenli (1) | BC Cancer, Vancouver, BC, CA, TRIUMF, Vancouver, BC, CA