Investigation of the HyperscintTM Plastic Scintillation Dosimetry System Performance in a 15 MeV electron beam at FLASH dose rates

4. FLASH-RT / UHDR, MeV Electron, Energy Dependency, Real-time Dosimetry Show more

The performance of the HYPERSCINT plastic scintillation dosimetry system in a 15 MeV electron beam operating at FLASH dose rates was investigated. The linac produced a 15 MeV electron FLASH beam with an average dose rate of ~250 Gy/s and dose per pulse between 1 Gy and 1.7 Gy, at the level just above the multi-leaf collimator. The HYPERSCINT plastic scintillator detector system agreed with OSLDs within 3.5% for 10 to 20 pulse FLASH deliveries using the standard dose rate calibration for both dosimeters.

2021 COMP ANNUAL SCIENTIFIC MEETING
C.Mendez, P.Petric, T.Karan, C.Duzenli | BC Cancer, Vancouver, BC, CA

EFLASH Dosimetry On a Conventional Linac Using Pulse-Gated Delivery

4. FLASH-RT / UHDR, 9. Advanced Dosimetry, MeV Electron, Detector comparaison, Energy Dependency, Fundamental Research, LINAC Pulse Discrimination, Real-time Dosimetry Show more

To build on previous experiments and improve reproducibility of electron FLASH delivery on a conventional linear accelerator, a pulse-gating circuit was constructed and tested with several dosimeters including : a 0.01cc volume ion chamber, optically stimulated luminescence dosimeters (OSLDs), Gafchromic MD film and a novel plastic scintillation detector with spectral analysis (HYPERSCINT).

2021 AAPM ANNUAL MEETING
C.Duzenli, C.Mendez, M.Petric, J.Sweeney, D.Ta, T.Karan | BC Cancer, Vancouver, BC, CANADA

FLASH Irradiation of Drosophila Melanogaster Using Low Energy X-Rays

4. FLASH-RT / UHDR, 5. In Vivo Dosimetry, kV Photon, Rabiobiology Show more

To investigate the capability of low energy x-rays to elicit the FLASH effect, Drosophila melanogaster larvae were irradiated with ultrahigh dose-rate and conventional radiotherapy dose rates using an inexpensive x-ray tube system. Dosimetry was performed with plastic scintillators and radiochromic film, and the differential survival observed in this work suggests that continuous 120 kVp x-rays can induce a FLASH effect.

2022 AAPM ANNUAL MEETING
A.Hart, J.Dudzic, J.Eby, S.Perlman, M.Bazalova-Carter | University of Victoria, Victoria, BC ,CA

Dosimetric Characterization of the ARIEL 10 MV X-Ray Ultrahigh Dose-Rate (FLASH) Irradiation Platform at TRIUMF

4. FLASH-RT / UHDR, 9. Advanced Dosimetry, MV Photon, Detector comparaison, Fundamental Research Show more

The purpose was to characterize the beam delivery capabilities and dose rates achievable on the new ultrahigh dose-rate 10MV x-ray irradiation platform at TRIUMF. Beam commissioning and dosimetry have been conducted on the ARIEL x-ray FLASH irradiation platform using film doses and scintillators. Measured dose rates support that the 10MV x-ray beam may be used as a UHDR source compatible with FLASH radiobiological experiments.

2022 AAPM ANNUAL MEETING
N.Esplen (1), L.Egoriti (2), T.Planche (3), A.Hart (1), B.Paley (3), C.Hoehr (3), A.Gottberg (3), M.Bazalova-Carter (1) | 1- University of Victoria, BC ,CA, 2- University of British Columbia, BC, CA, 3- TRIUMF, BC, CA

Plastic Scintillation Detector for Dosimetric Characterization of Mobetron Ultra-High Dose Rate Electron Beam

4. FLASH-RT / UHDR, 7. Commissioning, MeV Electron, Commissioning, Detector comparaison, Quality Assurance Show more

The purpose is to present commissioning data for the MOBETRON electron radiation therapy system (IntraOp) at ultra-high dose rate using the HYPERSCINT plastic scintillation detector. The suitability of using a plastic scintillator as an active dosimeter for commissioning measurements of an ultra-high dose rate electron beam has been demonstrated (reference dosimetry, DPP, beam penetration, linearity with number of pulses, linearity with PW and short-term output stability).

2022 AAPM ANNUAL MEETING
G.Famulari (1), K.Zerouali (1), O.Piron (1), JF.Aubry (1), F.DeBlois (1), JF.Carrier (2) | 1- Centre Hospitalier de l’Universite de Montreal (CHUM), Montreal, QC, CA, 2- Departement de Physique, Universite de Montreal, Montreal, QC, CA

Quantifying the DNA-damaging Effects of FLASH Irradiation With Plasmid DNA

4. FLASH-RT / UHDR, MeV Electron, Rabiobiology Show more

The objective is to investigate a plasmid DNA nicking assay approach for isolating and quantifying the DNA-damaging effects of ultrahigh-dose-rate (ie FLASH) irradiation relative to conventional dose-rate irradiation. The doses and dose rates were verified independently using EBT-XD Gafchromic film placed directly above the DNA-based phantom and HYPERSCINT high temporal resolution plastic scintillator placed immediately beside the DNA phantoms (both phantoms had been previously calibrated at conventional dose rates and validated at FLASH-RT dose rates).

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY, BIOLOGY, PHYSICS
A.Perstin (1), Y.Poirier (2), A.Sawant (2), M.Tambasco (1) | 1- Department of Physics, San Diego State University, CA, USA, 2- Department of Radiation Oncology, University of Maryland School of Medicine, Maryland, USA

Characterization of an x‐ray tube‐based ultrahigh dose‐rate system for in vitro irradiations.

4. FLASH-RT / UHDR, kV Photon, Rabiobiology, Real-time Dosimetry Show more

To present an x-ray tube system capable of in vitro ultrahigh dose-rate (UHDR) irradiation of small < 0.3 mm samples and to characterize it by means of a plastic scintillation detector (PSD).

Med Phys. 2021
D.Cecchi (1), F.Therriault-Proulx (2), S.Lambert-girard (2), A.Hart (1), A.Macdonald (1), M.Pfleger (1), M.Lenckowski (1), M.Bazalova-Carter (1) | Department of Physics and Astronomy, University of Victoria, Victoria, British Columbia, Canada, MedScint, QC, CA

Feasibility of Plastic Scintillator Dosimeters for FLASH Therapy

4. FLASH-RT / UHDR, MeV Electron, Advanced Optical Dosimetry Show more

To examine the capabilities of plastic scintillator dosimeters (PSDs) to accurately measure FLASH radiotherapy dose rates delivered with an x-ray tube.

2020 AAPM AM
D.Cecchi (1), F.Therriault-Proulx (2), M.Bazalova-Carter (1) | University of Victoria, Victoria, BC ,CA,, Medscint, QC, CA

Plastic and Lead-Doped Scintillators for Ultrahigh Dose-Rate Irradiations Delivered with An X-Ray Tube

4. FLASH-RT / UHDR, kV Photon, Custom Probe Development Show more

To examine the capabilities of plastic scintillators of different compositions to accurately measure dose in high dose-rate dose irradiations delivered with an x-ray tube.

2021 AAPM AM
D.Cecchi (1), C.Gigeure (2), F.Larose (2), F.Therriault-Proulx (3), L.Beaulieu (2), M.Bazalova-Carter (1) | University of Victoria, Victoria, BC ,CA,, CHU de Quebec – Universite Laval, QC, CA, MedScint, QC, CA

Evaluation of scintillation detectors for ultrahigh dose-rate x-ray beam dosimetry

4. FLASH-RT / UHDR, 5. In Vivo Dosimetry, kV Photon, Advanced Optical Dosimetry, Detector comparaison, Fundamental Research, Real-time Dosimetry Show more

FLASH-Radiotherapy is an emerging ultrahigh dose rates radiotherapy technique, and animal studies have demonstrated the safety and efficacy of the technique in cancer treatment. A reliable real-time dosimeter system is crucial for the characterization of the so-called ‘FLASH-effect’, and an accurate beam delivery. This study aims to benchmark the performance of optical fiber inorganic scintillating detectors (ISDs) with plastic scintillating detectors (PSDs) for an ultrahigh dose-rate x-ray beam irradiation. Measurements includes : relative scintillator output, signal linearity with dose and dose rate, signal-to-noise ratio (SNR), signal stability and reliability.

The PSDs resulted in the highest reliability for a UHDR beam measurement with a CV of <0.1% while the Gd2O2S:Tb showed excellent repeatability (coefficient of variation (CV) <0.1%) compared to other detectors. All detectors showed good linearity with tube current (R2 < 0.975) and shutter exposure (R2 >0.999).

Proc Spie
Shahirah Shaharuddin (1), Alexander Hart (2), Magdalena Bazalova-Carter (2), Luc Beaulieu (3), Cloe Giguere (3), Christoph Kleefeld (1), Mark J. Foley (1) | 1. National University of Ireland, Galway (Ireland), 2. University of Victoria (Canada), 3 University Laval (Canada)